IVF processes such as IMSI & ICSI are used to enhance the probability of pregnancies. These processes depend on visual Quality & Morphology of the embryos to select the best embryos for transplantations. These processes are unable to detect abnormalities passed on genetically by chromosomes. PGS / PGD are diagnostic procedures used for couples with increased risk of passing a chromosomal abnormality or specific genetic disorder on to their children.
PGS / PGD enables the genetic status of an embryo to be determined prior to embryo transfer.
PGS is comprehensive chromosome screening that examines embryos for chromosomal abnormalities. All 24 chromosomes (22 autosomes plus X and Y) are examined to evaluate any gains or losses of chromosomes.
This screening is recommended for couples exhibiting majority of IVF indications and particularly for advanced maternal aged couples.
The information includes
- Chromosomal Duplications: An extra copy of chromosome 21 also known as Downs Syndrome and other such conditions
- Chromosomal Deletions: Missing copies of chromosomes
- Sex-chromosome abnormalities: Duplications and deletions of X & Y chromosomes which can cause many abnormalities
- Gender Identification: This information is currently not provided per the Laws and Regulations of India. We do not provide service for Gender Identification
PGS aims at improving pregnancy and live birth rates by screening your embryos for chromosomal abnormalities and only implanting chromosomally normal embryos. PGS is used for testing chromosomal abnormalities only, testing of a specific gene or mutation is performed by PGD.
PGD provides indication whether a specific genetic disease affects an embryo. Families affected by any genetic disease should use this test to reduce the risk of their progeny carrying the genetic disease. PGD helps prevent genetic disease and improves success rates for IVF. This process requires a biopsy of the embryo to be performed on Day 3 or Day 5 as per the recommendations of the IVF Consultant. This biopsy is a highly specialised and skilled procedure carried out by our Senior Embryologists only. The results of PGD take a few days and the embryos’ are generally frozen while we await the results. A Frozen Embryo Transfer is then planned in the subsequent cycle.
Couples choose PGD and PGS for many reasons, including repeat implantation failure, repeat miscarriage, an objection to termination of pregnancy, or loss of a child from the genetic disease.